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KMID : 1149220090170010099
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Korean Journal of Oriental Medical Prescription
2009 Volume.17 No. 1 p.99 ~ p.111
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Anti-rheumatiod Arthritis Effects of I-Myo-San Water Extract
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Im Chang-Gyeong
Yun Young-Gab
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Abstract
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Rheumatoid arthritis is characterized by focal loss of cartilage due to an up-regulation of inflammatory pathways, which produce pro-inflammatory mediators, such as interleukin-1(IL-1), tumour necrosis factor alpha(TNF-α), prostaglantin, and nitric oxide(NO). We investigated the anti-arthritic effects of water extracts from Pellodendri cortex and Atractylodis rhizoma in vitro and in vivo. Each extract suppressed the production of inflammatory mediators(NO, IL-1β, TNF-α, and prostaglandin E2) and the expression of inducible NO synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated macrophages in a dose-dependent manner. These suppressive effects were synergistically increased by their combination. The same results were also observed in the rat osteoblast sarcoma cell line ROS17/2.8 stimulated with IL-1β, IFN-γ, and TNF-α. Moreover, the combination of these water extracts significantly suppressed collagen-induced mouse arthritis. These results suggest that the combination of water-extractable components of Pellodendri cortex and Atractylodis rhizoma may be useful for therapeutic drugs against rheumatoid arthritis, probably by suppressing the production of inflammatory mediators.
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KEYWORD
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I-Myo-San, rheumatoid arthritis, Pellodendri cortex, nflammatory mediators, Atractylodis rhizoma
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